The Human Functional Genomics Project

About this project

Human functional genomics project is based on integrating multi-layers of molecular data to help understand disease mechanisms better. This systems approach enable us to identify novel targets and/or validate existing targets. 

Cohorts of healthy volunteers: 

• cohorts of healthy individuals with different genetic backgrounds: 
• Western-European Netherlands (3 cohorts done: n=500, 200, 1600) 
• Eastern-Europeans Romania (inclusion started 2017) 
• Eastern-Africans Tanzania (n=300 completed) 
• Asians Indonesia (pending funding 2019) 

Cohorts of patients: 

• candidemia (330 completed) 
• sepsis (started 2017) 
• thyroid cancer (started end 2016) 
• bladder cancer (started 2017) 
• rheumatoid arthritis (n=400 completed) 
• recurrent Vulvo-vaginal Candidiasis (started 2017) 
• obesity +/- cardiovascular diseases (300 completed) 
• Gout (started June 2016) 
• type 1 diabetes (200 completed) 
• BCG vaccination cohort (n=300, 3 time points, started 2017) 
• Crohn’s disease (to start end 2018) 
• HIV (200 completed)